Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome
Posted on Tue 15 March 2005 in publication • Tagged with research, immunology
Interleukin-1 (IL-1) is a key driver of inflammation, and the body makes its own blocker for it: the IL-1 receptor antagonist (IL-1Ra). Most IL-1Ra works outside cells, but three of its four forms stay inside them, and what those inner forms do was unknown.
This study from the University of …
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